TURNAROUND TIME OF RESULTS OF BLOODSTREAM AND WOUND INFECTIONS CAUSED BY EXTENDED SPECTRUM BETA LACTAMASE POSITIVE ESCHERICHIA COLI AT MAKERERE UNIVERSITY CLINICAL MICROBIOLOGICAL LABORATORY. A CROSS-SECTIONAL STUDY.
DOI:
https://doi.org/10.70572/agp.v1i10.6Keywords:
Makerere University, Blood and Wound Infections, Turnaround Time, Beta Lactamase Positive Escherichia ColiAbstract
Background
The production of extended-spectrum beta-lactamase (ESBL) enzymes is a common mechanism by which Escherichia coli develops resistance to antibiotics. Timely detection and reporting of ESBL-producing E. coli is crucial, particularly in cases of bloodstream and wound infections. Therefore, this study aimed to determine the Turnaround Time of Results of Bloodstream and Wound Infections Caused by Extended Spectrum Beta Lactamase Positive Escherichia Coli at Makerere University Clinical Microbiological Laboratory.
Methodology
This study was a cross-sectional retrospective analysis of lab records for ESBL-positive E. coli isolated from blood and pus samples received between the periods of January 2019 to March 2021 at the Makerere University Clinical Microbiology Laboratory, purposive sampling technique was used to select only records for which ESBL positive E.coli.
Results
For bloodstream infections, out of 91 E. coli-positive samples received between January 2019 and March 2021, 69.23% (63 samples) were processed within the standard 3-5 days as per lab SOPs. However, 26.3% (24 samples) took 6-8 days, and 4.4% (4 samples) required 9-11 days for processing. For wound infections, out of 85 samples, 61.18% (52 samples) were processed within 3-5 days, while 21.18% (18 samples) took 6-8 days, 3.53% (3 samples) took 9-11 days, and 14.12% (12 samples) exceeded 11 days for result processing.
Conclusion
From the study findings, it was noted that most samples were processed based on the standard operating procedures (SOPS) of the lab, except for 8 blood samples that were not cultured on MAC and blood agar and 2 pus swabs whose gram stain was not indicated.
Recommendation
The samples should be processed based on the standard operating procedures (SOPS) of the lab to avoid analytical errors.
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